Isolera™ LS 150 Flash Chromatography System
The Isolera™ LS 150 Flash Chromatography System is an advanced, fully automated purification platform specifically designed to bridge the gap between laboratory-scale research and process-scale production. This robust system handles sample loads up to 800 grams per run and flow rates up to 500 mL/min, making it ideal for high-capacity purification of organic compounds, pharmaceutical intermediates, and fine chemicals. Engineered for scalability, the Isolera™ LS 150 simplifies process development with pre-packed columns ranging from 50 g to 8 kg, intelligent gradient control, and easy method transfer from TLC plates to large flash columns. Its intuitive, large touchscreen interface offers real-time 3D peak visualization, gradient equilibration, automated fraction collection, and precise solvent delivery to ensure high reproducibility and optimal separation performance.
- High-Capacity Processing — Supports up to 800 g per purification run with flow rates reaching 500 mL/min.
- Wide Column Range Compatibility — Operates with prepacked columns from 50 g to 8 kg for safe, efficient scaling.
- Intelligent Software Control — Features automated fraction collection, gradient equilibration, and real-time 3D peak visualization.
- Flexible Scale-Up Options — Easily transfer methods from TLC plates to flash columns, supports isocratic and step gradients.
- Touchscreen User Interface — Large, intuitive touchscreen for full method control and simplified operations.
- Process Security & Reproducibility — Ensures consistent, reliable results in both development and production environments.
- Ideal for Process Development — Bridges the gap between R&D purification and pilot/production-scale manufacturing.
- Process Development in Pharmaceutical Manufacturing
- Large-Scale Organic Compound Purification
- Fine Chemical Production
- Biotechnology Downstream Processing
- Method Transfer from Lab to Pilot Scale
- Chemical Process Engineering
| Parameter | Specification |
|---|---|
| Weight | 42–46 kg (93–102 lbs), depending on system configuration |
| Dimensions (W × D × H) | Isolera™ LS 150: 577 × 497 × 596 mm (22.7" × 19.6" × 23.5")Flash 150 column: 56 × 56 × 106 mm (22" × 22" × 42") |
| Flow Rate Range | 50 – 500 mL/min |
| Fraction Collection Modes | Volume, threshold, threshold with volume, low slope, medium slope |
| Solvent Delivery | Two constant volume (11-mL) electric HPFC pumps |
| Power Requirements | 100 – 240 VAC, 50/60 Hz, 4.0 A |
| Collection Vessels | Test tubes (13, 16, 18, and 25 mm) and bottles (120 mL, 240 mL, 480 mL) |
| UV Detection | 200–800 nm (Isolera™ LS 150 system). Upgrade kit retrofittable to 200–400 nm or to 200–800 nm |
| UV Collection Modes | Single, dual, λ-All wavelengths (variable UV and UV-VIS) |
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